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Aging, Reproduction, and the Climacteric by Caleb E. Finch, Roger G. Gosden (auth.), Luigi Mastroianni

By Caleb E. Finch, Roger G. Gosden (auth.), Luigi Mastroianni Jr., C. Alvin Paulsen (eds.)

Interest in sexuality and reproductive functionality doesn't stop whilst humans start to age. in its place, a brand new set of questions arises. girls need to know whether it is secure to have infants of their past due thirties and early forties. they need to understand extra approximately sizzling flashes and different signs of menopause-which ones are risky and that are purely uncomfortable. they're wanting to know about the relative hazards and merits of estrogen alternative remedy. males, too, are occupied with age-related adjustments of their sexual functionality. specialists in reproductive body structure, gerontology, and genetics met on the nationwide Institutes of overall healthiness in June of 1984 to debate those and different issues approximately getting older and the reproductive method. The convention on getting older, Reproduc­ tion, and the Climacteric used to be backed through the yank Fertility Society, The nationwide Institute on getting older, and the nationwide Institute of kid wellbeing and fitness and Human improvement. This quantity is predicated at the complaints of that confer­ ence.

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Tang, V. , 1983, Premature ovarian failure: A search for circulating factors against gonadotropin receptors, Am. J. Obstet. Gynecol. 146:816-821. , 1982, Similar does-related chromosome non-disjunction in young and old female after X-irradiation, Mut. Res. 95:287-296. , Hart, S. , 1973, Menopausal age and symptomatology in general practice, J. Biosocial. Sci. 5:71-82. Thung, P. , Boot, D. , 1956, Senile changes in the estrous cycles and in ovarian structure in some inbred strains of mice, Acta Endocrinol.

Aging 2:251-314. Nordin, B. E. , Marshall, D. , Francis, R. , and Crilly, R. , 1981, The effects of sex steroids and corticosteroid hormones on bone, 1. Steroid. Biochem. 15:171-174. Novak, E. , 1970, Ovulation after 50, Obstet. Gynecol. 36:903-910. Novak, E. , Jones, G. , O'Toole, R. , 1965, Enzyme histochemistry of the menopausal ovary associated with normal and abnormal endometrium, Am. 1. Obstet. Gynecol. 93:669-680. Odell, W. , and Swerdloff, R. , 1968, Progesterone-induced luteinizing and follicle-stimulat- ° 32 CALEB E.

Laboratory Animal Genetic Center (Bethesda MDl. The resulting C57BLl6N mice were sent in 1975 to Charles River Laboratories (Wilmington. MAl to establish a breeding stock for an aging colony initially contracted by the National Institute of Aging (Bethesda. MDl. and are designated C57BLl6NNia. The C57BLI 6NNia may not be strictly identical with C57BLl6J or C57BLl6N genotypes. 21 ANIMAL MODELS FOR THE HUMAN MENOPAUSE BASAL LH 150 E .... 100 X 50 ....... J 0 3 6 9 12 N ........... ~I;~!! 15 24 MONTHS E2 - INDUCED LH SURGE 500 E ....

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