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An Introduction to Medicinal Chemistry (5th Edition) by Graham L. Patrick

By Graham L. Patrick

An advent to Medicinal Chemistry is the major textual content for college classes in this topic. popular for being a textbook enjoyed both by means of either scholars and teachers, it offers whole assurance in an available and fascinating type.

The textual content starts with the fundamental biochemistry on which an figuring out of medicinal chemistry is outfitted, introducing the constitution and serve as of vital drug ambitions. It then explores how medicines have interaction with the physique and the results of these reactions. there's a part on basic ideas and techniques inquisitive about getting to know and designing new medicines, and one other on worthwhile 'tools of the trade'. The textual content ends with a latest examine particular themes inside medicinal chemistry, for instance, antiviral and anticancer brokers; cholinergics and anticholinesterases; and antiulcer agents.

Learning beneficial properties all through An advent to Medicinal Chemistry support to free up this interesting topic. A thesaurus is helping to familiarise the language of medicinal chemistry. packing containers current in-depth fabric and discover how strategies are utilized in perform. Key issues summarise sections inside chapters, delivering a foundation for revision, and questions on the finish of chapters and at the accompanying on-line source Centre let the reader to check their realizing and enhance molecular modelling skills.

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Extra resources for An Introduction to Medicinal Chemistry (5th Edition)

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For example, steroids share a similar tetracyclic structure, but they have very different effects in the body. 5, Chapter 24 and Case study 6). These are examples of compounds with a similar structure and similar mechanism of action. However, there are exceptions. Most sulphonamides are used as antibacterial agents, but there are a few which have totally different medical applications. By target system Drugs can be classified according to whether they affect a certain target system in the body.

By target molecule Some drugs are classified according to the molecular target with which they interact. 15) are drugs which act by inhibiting the enzyme acetylcholinesterase. This is a more specific classification as we have now identified the precise target at which the drugs act. In this situation we might expect some structural similarity between the agents involved and a common mechanism of action, although this is not an inviolable assumption. However, it is easy to lose the wood for the trees and to lose sight of why it is useful to have drugs which switch off a particular enzyme or receptor.

It has been proposed that the pi (π) systems present in alkynes and aromatic rings are regions of high electron density and can act as hydrogen bond acceptors. However, the electron density in these systems is diffuse and so the hydrogen bonding interaction is much weaker than those involving oxygen or nitrogen. As a result, aromatic rings and alkynes are only likely to be significant hydrogen bond acceptors if they interact with a strong hydrogen bond donor, such as an alkylammonium ion (NHR3+).

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