By Prof. David A. Phoenix, Dr. Sarah R. Dennison, Dr. Frederick Harris(auth.)
During this didactically-written textual content, the small workforce of specialist authors provides the sphere in a complete and available demeanour that's compatible for college students and junior researchers.
the result's a hugely readable and systematically based creation to antimicrobial peptides, their constitution, organic functionality and mode of motion. The authors element the best way in the direction of a rational layout of this in all probability powerful new classification of medical antibiotics near to commercial program by way of discussing their layout ideas, goal membranes and structure-activity relationships. the ultimate a part of the publication describes contemporary successes within the program of peptides as anticancer agents.Content:
Chapter 1 Antimicrobial Peptides: Their heritage, Evolution, and practical Promiscuity (pages 1–37):
Chapter 2 Cationic Antimicrobial Peptides (pages 39–81):
Chapter three Anionic Antimicrobial Peptides (pages 83–113):
Chapter four Graphical concepts to imagine the Amphiphilic buildings of Antimicrobial Peptides (pages 115–144):
Chapter five versions for the Membrane Interactions of Antimicrobial Peptides (pages 145–180):
Chapter 6 Selectivity and Toxicity of Oncolytic Antimicrobial Peptides (pages 181–221):
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Additional resources for Antimicrobial Peptides
And Wu, M. (2011) Defensins in innate immunity. Cell and Tissue Research, 343, 175–188. I. (2003) Evolution of primate theta-defensins: a serpentine path to a sweet tooth. Peptides, 24, 1647–1654. D. M. (2011) Plant defensins and defensin-like peptides – biological activities and biotechnological applications. Current Pharmaceutical Design, 17, 4270–4293. , and Shah, D. (2011) Can plant defensins be used to engineer durable commercially useful fungal resistance in crop plants? Fungal Biology Reviews, 25, 128–135.
And White, A. (2007) Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB Journal, 21, 1844–1856. , and Gatti, S. (2006) Antimicrobial properties of alpha-MSH and related synthetic melanocortins. TheScientificWorldJournal, 6, 1241–1246. , and Catania, A. (2000) Antimicrobial effects of alpha-MSH peptides. Journal of Leukocyte Biology, 67, 233–239. , and Baroni, A. (2004) Alpha-MSH reduces the internalization of Staphylococcus 32 1 Antimicrobial Peptides: Their History, Evolution, and Functional Promiscuity aureus and down-regulates HSP 70, integrins and cytokine expression in human keratinocyte cell lines.
Influenzae. Bulletin of the World Health Organization, 79, 780–790. 11 Brown, K. (2004) The history of penicillin from discovery to the drive to production. Pharmaceutical Historian, 34, 37–43. H. (2012) History of antibiotics. From Salvarsan to Cephalosporins. Journal of Investigative Surgery, 25, 67–77. 13 Bentley, R. (2009) Different roads to discovery; Prontosil (hence sulfa drugs) and penicillin (hence beta-lactams). Journal of Industrial Microbiology & Biotechnology, 36, 775–786. , and Carbonero, P.